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Abemaciclib

Abemaciclib Patient Handout What is Abemaciclib? Abemaciclib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs known as cyclin-dependent kinase (CDK) inhibitors. It works by blocking proteins (CDK4 and CDK6) that promote cancer cell growth, thereby slowing or stopping the progression of the disease. How to Take Abemaciclib
  • Dosing: The typical starting dose is 150 mg taken orally twice daily. Your healthcare provider may adjust the dose based on your response or any side effects.
  • Do not crush, chew, or break the tablets. Swallow them whole with water.
Possible Side Effects Abemaciclib can cause side effects. Common ones include:
  • Diarrhea
  • Nausea and vomiting
  • Fatigue
  • Decreased appetite
  • Low white blood cell count (neutropenia)
  • Hair thinning or loss
Less common but serious side effects:
  • Blood clots (swelling, redness, or pain in the limbs, chest pain, or difficulty breathing)
  • Liver problems (yellowing of the skin or eyes, dark urine, or upper stomach pain)
  • Severe infections
If you experience severe or concerning symptoms, contact your healthcare provider immediately. Pregnancy Precautions
  • Do not take Abemaciclib if you are pregnant or planning to become pregnant. This medication can harm an unborn baby.
  • Use effective birth control during treatment and for at least 3 weeks after your last dose.
  • If you think you are pregnant while taking Abemaciclib, contact your doctor immediately.
Storage
  • Store Abemaciclib at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep the medication in its original container, away from moisture and light.
  • Keep out of reach of children.
What to Do If You Miss a Dose
  • If you miss a dose, take it as soon as you remember unless it is close to the time for your next dose.
  • Do not take two doses at the same time. Skip the missed dose if it is almost time for your next scheduled dose.
Before Taking Abemaciclib, Tell Your Doctor If:
  • You have a history of liver or kidney problems.
  • You have any infections or a history of low blood cell counts.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, vitamins, or herbal supplements.
When to Contact Your Physician
  • Immediately:
    • If you experience symptoms of a blood clot (e.g., chest pain, swelling in the limbs).
    • Signs of severe infection (e.g., fever, chills, persistent cough).
    • Symptoms of liver problems (e.g., yellowing of the skin or eyes, dark urine).
  • As soon as possible:
    • If you experience persistent diarrhea, nausea, or vomiting that does not improve with supportive care.
    • If you notice any unusual or severe side effects.
Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.