Patient Handout: Understanding Bosutinib (Bosulif)
What is Bosutinib?
Bosutinib (brand name: Bosulif) is a prescription medication used to treat certain types of blood cancers, including:
- Chronic myeloid leukemia (CML) in adults with Philadelphia chromosome-positive (Ph+ CML)
Bosutinib is a tyrosine kinase inhibitor (TKI) that works by blocking specific proteins in cancer cells, slowing their growth or causing them to die.
How to Take Bosutinib
- Dosage: Take Bosutinib exactly as prescribed by your doctor. The dose may vary depending on your condition and response to treatment.
- With Food: Always take Bosutinib with food to improve absorption and reduce the risk of stomach upset.
- Swallow Whole: Swallow the tablet whole; do not crush, chew, or split it.
- Missed Dose: If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose. Do not double up.
- Storage: Store Bosutinib at room temperature in its original container, away from moisture and heat.
Potential Side Effects
Common side effects include:
- Diarrhea
- Nausea or vomiting
- Stomach pain
- Fatigue
- Increased liver enzyme levels (found during blood tests)
Serious side effects (contact your doctor immediately if you experience):
- Severe diarrhea or dehydration
- Unusual bruising or bleeding
- Signs of liver problems (yellowing of the skin or eyes, dark urine, severe abdominal pain)
- Symptoms of infection (fever, chills, persistent sore throat)
- Severe swelling or shortness of breath
Precautions
- Before Starting Bosutinib:
- Inform your doctor if you have liver, kidney, or heart problems.
- Discuss all medications you are taking, including over-the-counter drugs and supplements.
- Pregnancy and Breastfeeding:
- Bosutinib can harm an unborn baby. Avoid becoming pregnant while on this medication.
- Do not breastfeed while taking Bosutinib.
- Drug Interactions:
- Avoid grapefruit and grapefruit juice, as they can affect how Bosutinib is absorbed.
- Let your doctor know about any medications that may interact with Bosutinib.
- Regular Monitoring:
- Your doctor will perform regular blood tests to monitor your response to treatment and check for side effects.
Tips for Managing Side Effects
- Diarrhea: Stay hydrated and consider over-the-counter anti-diarrheal medications after consulting your doctor.
- Nausea: Take the medication with food and avoid heavy, greasy meals.
- Fatigue: Rest as needed and maintain a balanced diet.
When to Contact Your Doctor
Seek medical attention if you experience:
- Persistent or severe side effects
- Symptoms of an allergic reaction, such as rash, itching, or swelling
- Worsening of your condition
Disclaimer: This handout is for informational purposes only and does not replace professional medical advice. Always consult your healthcare provider for personalized guidance.