Patient Handout: Capivasertib (Capivasertib)

What is Capivasertib?

Capivasertib is an oral medication currently being investigated as a treatment for certain types of cancer, particularly HR-positive, HER2-negative breast cancer with PIK3CA mutations. It is often used in combination with other treatments such as aromatase inhibitors (e.g., letrozole) or other targeted therapies.

Capivasertib is part of a class of drugs known as AKT inhibitors, and it works by blocking a protein called AKT, which plays a critical role in the growth, survival, and spread of cancer cells.

How Does Capivasertib Work?

Capivasertib works by targeting and inhibiting AKT, a protein that helps regulate key cell processes such as growth and survival. When cancer cells have overactive AKT signaling, they can grow uncontrollably. By blocking AKT, capivasertib aims to slow or stop cancer cell growth, making it easier for other treatments (such as chemotherapy or hormonal therapy) to work effectively.

How is Capivasertib Taken?

• Form: Capivasertib is taken as a tablet.
• Dosage: The typical dosage of capivasertib will be determined by your healthcare provider based on your specific situation and the type of cancer being treated. The most common dose is 400 mg, taken once daily, though your doctor may adjust this based on how well you tolerate the medication.
• Administration: Take capivasertib once daily. You can take the medication with or without food.
• Swallow the Tablet: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.

Possible Side Effects

Capivasertib may cause side effects, although not everyone will experience them. Some side effects may be serious, and you should contact your healthcare provider if you experience any of the following:

Common Side Effects:

• Diarrhea: Diarrhea is a common side effect of capivasertib. Make sure to stay hydrated, and contact your doctor if diarrhea becomes severe or persistent.
• Nausea and Vomiting: Nausea and vomiting can occur. Your doctor may recommend medications to help prevent or treat these symptoms.
• Fatigue: Many patients experience tiredness or weakness while on capivasertib. It’s important to rest, but let your doctor know if fatigue becomes severe or interferes with your daily activities.
• Appetite Loss: Loss of appetite can occur. Eating smaller, more frequent meals may help.
• Rash: Some people may develop a rash while taking capivasertib. If the rash is bothersome or severe, contact your healthcare provider.
• Elevated Liver Enzymes: Capivasertib can affect your liver function, leading to changes in liver enzymes. Your doctor may monitor your liver health through blood tests.

Serious Side Effects:

• Liver Damage: Capivasertib can cause liver toxicity. Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, or pain in the upper right side of your abdomen. Notify your doctor immediately if you experience any of these symptoms.
• Infections: Capivasertib can affect your immune system and increase the risk of infections. Contact your healthcare provider if you have symptoms of an infection such as fever, chills, or sore throat.
• Severe Diarrhea or Dehydration: Prolonged or severe diarrhea can lead to dehydration, so it’s important to stay hydrated. If diarrhea is persistent, seek medical advice.
• Heart Problems: Though rare, capivasertib may cause heart problems such as irregular heart rhythms. Symptoms may include shortness of breath, dizziness, or chest pain. Let your doctor know if you experience any of these symptoms.

Precautions Before Taking Capivasertib

Before starting capivasertib, inform your healthcare provider if you:

• Have Liver Problems: Since capivasertib can affect liver function, it’s important to inform your doctor if you have any history of liver disease.
• Have Heart Problems: If you have a history of heart disease or irregular heart rhythms, let your doctor know, as capivasertib can affect the heart.
• Are Pregnant or Planning to Become Pregnant: Capivasertib can harm an unborn baby. It’s important to use effective contraception while taking capivasertib and for a certain period after stopping it. Do not take capivasertib if you are pregnant.
• Are Breastfeeding: It’s not known if capivasertib passes into breast milk, so breastfeeding is not recommended while taking this medication.
• Have Diabetes: Capivasertib may affect blood sugar levels, so your doctor may need to monitor your blood sugar if you have diabetes or are at risk of developing it.
• Are Taking Other Medications: Some drugs may interact with capivasertib, so be sure to inform your healthcare provider of all the medications you are taking, including prescription, over-the-counter, and herbal supplements.

What to Avoid While Taking Capivasertib

• Grapefruit and Grapefruit Juice: Avoid consuming grapefruit or grapefruit juice, as they may interfere with how capivasertib is processed in your body.
• Live Vaccines: Do not receive live vaccines while taking capivasertib unless advised by your doctor. Live vaccines may not be safe during treatment.
• Infections: Capivasertib can weaken your immune system. Avoid close contact with people who are sick and practice good hygiene, such as frequent handwashing.

Regular Monitoring

Your healthcare provider will monitor your health regularly while you are on capivasertib. This may include:

• Blood Tests: Your doctor will perform blood tests to monitor your liver function, kidney function, blood counts, and blood sugar levels.
• Heart Monitoring: If you have a history of heart issues, your doctor may monitor your heart function during treatment.
• Infection Monitoring: Since capivasertib can weaken the immune system, your doctor may check for signs of infections.

When to Contact Your Doctor

Call your healthcare provider or seek immediate medical attention if you experience any of the following:

• Signs of liver problems: Yellowing of the skin or eyes (jaundice), dark urine, or pain in the upper abdomen.
• Severe diarrhea: Persistent diarrhea that leads to dehydration.
• Signs of infection: Fever, chills, sore throat, or unusual fatigue.
• Heart problems: Shortness of breath, chest pain, dizziness, or irregular heartbeat.
• Severe rash or other skin reactions: Blistering, peeling, or swelling of the skin.

Disclaimer:

This handout is for educational purposes only and should not be considered medical advice. Always follow the instructions provided by your healthcare provider regarding treatment and care. For personalized advice, consult your healthcare provider or pharmacist.