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Patient Handout: Encorafenib and Binimetinib (Braftovi + Mektovi)

What are Encorafenib and Binimetinib?

Encorafenib (brand name Braftovi) and binimetinib (brand name Mektovi) are two medications used together to treat certain cancers, particularly melanoma, a type of skin cancer. These drugs are targeted therapies that work by blocking specific proteins that contribute to cancer cell growth.

  • Encorafenib is a BRAF inhibitor. It works by blocking the BRAF protein, which is often mutated in certain cancers, including melanoma. By inhibiting BRAF, encorafenib helps to slow or stop the growth of cancer cells.
  • Binimetinib is a MEK inhibitor. It works by blocking the MEK protein, which is part of the same signaling pathway as BRAF. This pathway is often activated in cancer cells, promoting their growth. By inhibiting MEK, binimetinib helps stop cancer cells from dividing and growing.

Together, encorafenib and binimetinib work in tandem to target different parts of the same pathway, improving the effectiveness of treatment.

How Do Encorafenib and Binimetinib Work Together?

Cancer cells can grow uncontrollably when specific proteins, such as BRAF and MEK, are overactive. In many cancers, the BRAF gene is mutated, leading to abnormal cell growth.

Encorafenib blocks the mutated BRAF protein, while binimetinib inhibits MEK, another protein that works in the same signaling pathway. By targeting both BRAF and MEK, the combination therapy prevents cancer cells from growing and spreading.

How Are Encorafenib and Binimetinib Taken?

Both encorafenib and binimetinib are taken by mouth in the form of tablets.

  • Encorafenib (Braftovi): Usually taken once a day.
  • Binimetinib (Mektovi): Usually taken twice a day, once in the morning and once in the evening.

Important Administration Information:

  • Take both medications exactly as prescribed by your doctor.
  • You can take these medications with or without food.
  • Try to take the medications at the same time each day to help you remember.
  • If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.

Possible Side Effects

Encorafenib and binimetinib can cause side effects, some of which may be serious. It is important to discuss any concerns with your doctor and report any unusual symptoms.

Common Side Effects:

  • Fatigue: Tiredness or weakness can occur. It’s important to rest as needed.
  • Rash: Skin rashes are common and can range from mild to severe. Report any severe rashes to your doctor.
  • Diarrhea: You may experience loose stools. Make sure to drink plenty of fluids to stay hydrated.
  • Nausea and Vomiting: Some people experience nausea or vomiting. Your doctor may prescribe anti-nausea medications if necessary.
  • Headache: A headache may occur during treatment.
  • Joint and Muscle Pain: Some patients experience pain in their joints and muscles.
  • Fever: A mild fever may occur, and you should report if it becomes persistent or high.

Serious Side Effects:

  • Heart Problems: Binimetinib can cause heart problems, such as a decrease in heart function. Contact your doctor immediately if you experience chest pain, shortness of breath, or swelling in the legs.
  • Liver Issues: Both drugs can affect liver function. Symptoms of liver problems include yellowing of the skin or eyes, dark urine, or upper-right abdominal pain.
  • Vision Changes: Vision problems, including blurred vision, can occur with binimetinib. Report any changes in your vision to your doctor.
  • Severe Skin Reactions: Severe rashes or skin irritation, including blistering, can occur. If you experience severe skin problems, contact your doctor right away.
  • Serious Bleeding: Both drugs may increase the risk of bleeding. Seek medical attention if you experience unusual bruising, bleeding, or nosebleeds.

Precautions Before Taking Encorafenib and Binimetinib

Before starting treatment with encorafenib and binimetinib, inform your healthcare provider if you:

  • Have heart problems, such as irregular heartbeats or heart failure, as binimetinib can affect heart function.
  • Have liver problems, since both drugs are metabolized by the liver.
  • Have vision problems, as binimetinib can cause eye issues.
  • Are pregnant or planning to become pregnant: Encorafenib and binimetinib can harm an unborn baby. Use effective birth control during treatment and for at least 2 weeks after the last dose of encorafenib and 1 month after the last dose of binimetinib.
  • Are breastfeeding: Both medications may pass into breast milk, so breastfeeding is not recommended while on this treatment.

What to Avoid While Taking Encorafenib and Binimetinib

  • Pregnancy: Encorafenib and binimetinib can harm an unborn baby, so avoid becoming pregnant during treatment. Use contraception during treatment and for a time after stopping the medications.
  • Sun Exposure: Both medications can make your skin more sensitive to the sun. Avoid excessive sun exposure and use sunscreen and protective clothing when outdoors.
  • Live Vaccines: You should not receive live vaccines during treatment, as your immune system may be weakened by these drugs.
  • Grapefruit: Avoid grapefruit and grapefruit juice, as they may interact with the medications and affect how they work in your body.

Regular Monitoring

Your healthcare provider will need to monitor your health regularly throughout treatment with encorafenib and binimetinib. This may include:

  • Blood tests: To monitor liver function, heart function, and blood counts.
  • Skin exams: To check for any skin changes or new skin cancers.
  • Heart function tests: To check for any heart issues related to treatment.
  • Eye exams: To monitor for vision changes.

When to Contact Your Doctor

Contact your healthcare provider immediately if you experience any of the following:

  • Chest pain, shortness of breath, or swelling in the legs (possible heart issues)
  • Yellowing of the skin or eyes, dark urine, or abdominal pain (possible liver problems)
  • Severe rash or blistering skin
  • Blurred vision or other eye problems
  • Signs of bleeding, such as unusual bruising, nosebleeds, or blood in your urine or stool
  • Persistent fever or chills
  • Severe diarrhea, dehydration, or blood in your stool

Disclaimer:

This handout is for educational purposes only and should not be considered medical advice. Always follow the instructions provided by your healthcare provider regarding treatment and care. For personalized advice, consult your healthcare provider or pharmacist.