FOLFOX Toxicity Profile
Common side effects of FOLFOX adjuvant chemotherapy include:
- Hematologic toxicities:
– Neutropenia (27.8-40.3%)
– Anemia (34.7-76%)
– Thrombocytopenia (12.5-28%)
- Gastrointestinal toxicities (44%):
– Diarrhea (52.7%)
– Nausea (30.6%)
– Vomiting (27.8%)
– Oral mucositis (24%)
- Neurological toxicity:
– Peripheral sensory neuropathy (54.9-73.6%)
- Other toxicities:
– Fatigue (20.9%)
– Dermatological toxicity (9.7%)
Grade 3 or higher toxicities were reported in approximately 25% of patients receiving FOLFOX.