Inavolisib Patient Handout

What is Inavolisib?

Inavolisib is a targeted therapy medication used in the treatment of certain types of cancer. It works by inhibiting the PI3K (phosphoinositide 3-kinase) pathway, which is often overactive in cancer cells. This action helps to slow down or stop the growth of cancer cells.

How is Inavolisib Administered?

• Inavolisib is taken orally in the form of a tablet or capsule.
• The usual dose is 9mg once daily, but your specific dose will be determined by your healthcare provider based on your condition and overall treatment plan.
• Take the medication at the same time each day with a full glass of water.
• It can be taken with or without food, depending on your doctor’s instructions.
• Do not crush, chew, or break the tablets.

Possible Side Effects

Inavolisib can cause side effects. Common ones include:

• Nausea and vomiting
• Diarrhea
• Fatigue
• Decreased appetite
• Skin rash

Less common but serious side effects:

• Hyperglycemia (high blood sugar levels)
• Liver toxicity (elevated liver enzymes)
• Lung inflammation (pneumonitis)
• Severe infections

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Precautions Before Starting Inavolisib

• Inform your doctor if you have a history of:
  • Diabetes or blood sugar problems
  • Liver or kidney issues
  • Any other significant medical conditions
• Discuss all medications, vitamins, or supplements you are taking, especially those that affect blood sugar or the liver.
• Use effective contraception during treatment and for a period afterward, as Inavolisib can harm an unborn baby.
• Avoid live vaccines during treatment.

Managing Side Effects

• Nausea and vomiting: Anti-nausea medications may be prescribed. Eat small, bland meals as needed.
• High blood sugar: Monitor your blood sugar levels regularly if you have diabetes or are at risk. Inform your doctor of significant changes.
• Skin rash: Use gentle skincare products and inform your doctor if the rash worsens.
• Diarrhea: Stay hydrated and consult your doctor for anti-diarrheal medications if needed.

When to Contact Your Physician

• Immediately:
  • If you experience difficulty breathing or chest pain.
  • If you notice signs of infection, such as fever or chills.
  • If you have severe abdominal pain or persistent diarrhea.
• As soon as possible:
  • If you experience a significant rash or skin reaction.
  • If you notice unusual fatigue or yellowing of the skin/eyes (jaundice).
  • If you experience elevated blood sugar symptoms, such as increased thirst or frequent urination.

Storage and Handling

• Store Inavolisib at room temperature, away from moisture and heat.
• Keep the medication out of reach of children and pets.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.