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Letrozole

What is Letrozole?

Letrozole is a medication used to treat hormone receptor-positive breast cancer in postmenopausal women. It is also used to reduce the risk of recurrence of breast cancer. Letrozole belongs to a class of drugs called aromatase inhibitors, which work by lowering the levels of estrogen in the body. This helps slow or stop the growth of hormone-sensitive breast cancer cells.

How to Take Letrozole

  • Dosing: The usual dose is 2.5 mg taken orally once daily. Your healthcare provider will determine the appropriate duration of treatment.
  • Take Letrozole at the same time each day, with or without food.
  • Swallow the tablet whole with water. Do not crush or chew the tablet.

Possible Side Effects

Letrozole can cause side effects. Common ones include:

  • Hot flashes
  • Joint or muscle pain
  • Fatigue
  • Nausea
  • Headaches
  • Increased sweating
  • Vaginal dryness

Less common but serious side effects:

  • Bone thinning or osteoporosis, leading to an increased risk of fractures
  • Elevated cholesterol levels
  • Liver function changes

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Pregnancy Precautions

  • Letrozole is intended for postmenopausal women and should not be used during pregnancy.
  • If you are of childbearing potential, use effective contraception during treatment and for at least 3 weeks after stopping the medication.
  • If you think you are pregnant while taking Letrozole, contact your doctor immediately.

Storage

  • Store Letrozole at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep the medication in its original container, away from moisture and light.
  • Keep out of reach of children.

What to Do If You Miss a Dose

  • If you miss a dose, take it as soon as you remember.
  • If it is close to the time for your next dose, skip the missed dose. Do not take two doses at the same time.

Before Taking Letrozole, Tell Your Doctor If:

  • You have a history of osteoporosis or bone fractures.
  • You have high cholesterol or liver problems.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, vitamins, or herbal supplements.

When to Contact Your Physician

  • Immediately:
    • If you experience severe bone pain or fractures.
    • If you notice symptoms of liver problems (e.g., yellowing of the skin or eyes, dark urine).
    • If you experience severe allergic reactions, such as rash, itching, or swelling.
  • As soon as possible:
    • If you experience persistent joint or muscle pain.
    • If you notice unusual or severe side effects.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.