Patient Handout: Understanding Nilotinib (Tasigna)

What is Nilotinib?

Nilotinib (brand name: Tasigna) is a prescription medication used to treat certain types of blood cancers, including:

• Chronic myeloid leukemia (CML) in adults and children with Philadelphia chromosome-positive (Ph+ CML)

Nilotinib is a type of targeted therapy known as a tyrosine kinase inhibitor (TKI). It works by blocking specific proteins in cancer cells, slowing their growth or causing them to die.

How to Take Nilotinib

1. Dosage: Take Nilotinib exactly as prescribed by your doctor. The dose may vary depending on your condition and response to treatment.
2. Empty Stomach: Take Nilotinib on an empty stomach, either 2 hours after a meal or at least 1 hour before your next meal. Food can affect how the medication is absorbed.
3. Swallow Whole: Swallow the capsule whole; do not open, crush, or chew it.
4. Missed Dose: If you miss a dose, skip it and take your next dose at the regular time. Do not double up.
5. Storage: Store Nilotinib at room temperature in its original container, away from moisture and heat.

Potential Side Effects

Common side effects include:

• Nausea or vomiting
• Diarrhea or constipation
• Headache
• Rash or itching
• Fatigue

Serious side effects (contact your doctor immediately if you experience):

• Heart problems, such as irregular heartbeat or chest pain
• Unusual bruising or bleeding
• Severe abdominal pain
• Signs of liver problems (yellowing of the skin or eyes, dark urine)
• Symptoms of infection (fever, chills, persistent sore throat)

Precautions

1. Before Starting Nilotinib:
   • Inform your doctor if you have a history of heart problems, liver issues, or pancreatitis.
   • Discuss all medications you are taking, including over-the-counter drugs and supplements.
2. Pregnancy and Breastfeeding:
   • Nilotinib can harm an unborn baby. Avoid becoming pregnant while on this medication.
   • Do not breastfeed while taking Nilotinib.
3. Drug Interactions:
   • Avoid grapefruit and grapefruit juice, as they can affect how Nilotinib is absorbed.
   • Inform your doctor about all medications, as some may interact with Nilotinib.
4. Regular Monitoring:
   • Your doctor will perform regular blood tests and heart monitoring (ECG) to ensure your safety during treatment.

Tips for Managing Side Effects

• Nausea: Take the medication with water and avoid heavy, greasy meals shortly after.
• Rash: Use gentle skincare products and avoid harsh soaps. Contact your doctor if the rash worsens.
• Fatigue: Rest as needed and maintain a balanced diet.

When to Contact Your Doctor

Seek medical attention if you experience:

• Persistent or severe side effects
• Symptoms of an allergic reaction, such as rash, itching, or swelling
• Worsening of your condition

 

Disclaimer: This handout is for informational purposes only and does not replace professional medical advice. Always consult your healthcare provider for personalized guidance.