Paclitaxel Patient Handout

What is Paclitaxel?

Paclitaxel is a chemotherapy medication used to treat various types of cancer, including breast cancer, ovarian cancer, lung cancer, and Kaposi’s sarcoma. It belongs to a class of drugs called taxanes, which work by interfering with the microtubules inside cells, preventing cancer cells from dividing and growing.

How is Paclitaxel Administered?

• Paclitaxel is administered as an intravenous (IV) infusion in a hospital or clinic setting.
• The dose and frequency of treatment depend on your type of cancer, body size, and overall treatment plan as determined by your oncologist.
• You may receive pre-medications, such as corticosteroids and antihistamines, to reduce the risk of allergic reactions.

Possible Side Effects

Paclitaxel can cause side effects. Common ones include:

• Fatigue
• Nausea and vomiting
• Diarrhea
• Temporary hair loss
• Low blood cell counts (white cells, red cells, and platelets), which may increase the risk of infections, anemia, or bleeding
• Muscle or joint pain (myalgia/arthralgia)

Less common but serious side effects:

• Allergic reactions, such as rash, difficulty breathing, or swelling
• Severe infections due to low white blood cell counts (neutropenia)
• Numbness, tingling, or pain in the hands or feet (peripheral neuropathy)
• Liver toxicity
• Heart rhythm changes (rare)

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Precautions Before Starting Paclitaxel

• Inform your doctor if you have a history of:
  • Liver problems
  • Heart conditions
  • Allergies to medications or taxanes
  • Any other significant medical conditions
• Discuss all medications, vitamins, or supplements you are taking.
• Use effective contraception during treatment and for a period afterward, as Paclitaxel can harm an unborn baby.
• Avoid live vaccines during treatment.

Managing Side Effects

• Nausea and vomiting: Anti-nausea medications may be prescribed. Eat small, bland meals as needed.
• Low blood counts: Follow precautions to avoid infections, such as washing your hands frequently and avoiding sick individuals.
• Peripheral neuropathy: Report any numbness or tingling to your doctor, as your dose may need adjustment.
• Hair loss: Consider using head coverings if needed for comfort.
• Muscle or joint pain: Over-the-counter pain relievers may help, but consult your doctor first.

When to Contact Your Physician

• Immediately:
  • If you experience fever, chills, or signs of infection.
  • If you develop difficulty breathing, swelling, or severe rash.
  • If you have chest pain or irregular heartbeat.
• As soon as possible:
  • If you experience persistent nausea, vomiting, or diarrhea.
  • If you notice unusual bruising or bleeding.
  • If you have numbness, tingling, or pain in your hands or feet.

Storage and Handling

• Paclitaxel is administered by healthcare professionals and is not stored at home.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.