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Palbociclib Patient Handout

What is Palbociclib?

Palbociclib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called cyclin-dependent kinase (CDK) inhibitors. Palbociclib works by blocking proteins (CDK4 and CDK6) that promote cancer cell growth, slowing or stopping the progression of the disease.

How to Take Palbociclib

  • Dosing: The typical starting dose is 125 mg taken orally once daily for 21 consecutive days, followed by 7 days off in a 28-day cycle. Your healthcare provider may adjust your dose based on your response and side effects.
  • Take Palbociclib at the same time each day, with food.
  • Do not crush, chew, or split the capsules. Swallow them whole with water.

Possible Side Effects

Palbociclib can cause side effects. Common ones include:

  • Nausea and vomiting
  • Fatigue
  • Low blood cell counts (e.g., neutropenia, anemia)
  • Diarrhea
  • Hair thinning or loss

Less common but serious side effects:

  • Severe infections (e.g., fever, chills, persistent cough)
  • Lung inflammation (e.g., difficulty breathing, persistent cough)

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Pregnancy Precautions

  • Do not take Palbociclib if you are pregnant or planning to become pregnant. This medication can harm an unborn baby.
  • Use effective birth control during treatment and for at least 3 weeks after your last dose.
  • If you think you are pregnant while taking Palbociclib, contact your doctor immediately.

Storage

  • Store Palbociclib at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep the medication in its original container, away from moisture and light.
  • Keep out of reach of children.

What to Do If You Miss a Dose

  • If you miss a dose, skip it and take your next dose at the regular time.
  • Do not take two doses at the same time.

Before Taking Palbociclib, Tell Your Doctor If:

  • You have a history of liver, kidney, or lung problems.
  • You have any infections or a history of low blood cell counts.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, vitamins, or herbal supplements.

When to Contact Your Physician

  • Immediately:
    • If you experience symptoms of a severe infection (e.g., fever, chills, persistent cough).
    • If you have difficulty breathing or notice any signs of lung inflammation.
  • As soon as possible:
    • If you experience persistent nausea, vomiting, or diarrhea that does not improve with supportive care.
    • If you notice unusual or severe side effects.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.