Pertuzumab / Trastuzumab Side effects

Side Effect	Pertuzumab	Trastuzumab
Diarrhea	56.9% incidence	Common
Nausea	34.0% incidence	Common
Rash	25.6% incidence	Common, includes skin disorders
Fatigue	Common	Common
Febrile Neutropenia	Increased incidence in Asian patients (26%)	Not significantly increased
Cardiotoxicity	Not commonly reported	Up to 44% for LVEF decrease, 2-7% for symptomatic heart failure
Infusion Reactions	Not commonly reported	Common, includes chills and fever
Nephrotic Syndrome	Not commonly reported	Rare
Alopecia	Common when combined with docetaxel	Not commonly reported
Peripheral Neuropathy	Common when combined with docetaxel	Not commonly reported
Asthenia	Common	Common
Vomiting	Common	Common
Dyspnea	Not commonly reported	Common
Headache	Not commonly reported	Common

 

Citations:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440139/

[2] https://www.ncbi.nlm.nih.gov/books/NBK532246/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714930/

[4] https://www.nhs.uk/medicines/trastuzumab-herceptin/side-effects-of-trastuzumab/

[5] https://www.cancerresearchuk.org/about-cancer/treatment/drugs/trastuzumab

[6] https://www.drugs.com/sfx/herceptin-side-effects.html

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313340/

[8] https://www.rxlist.com/perjeta-drug.htm