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Ribociclib Patient Handout

What is Ribociclib?

Ribociclib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called cyclin-dependent kinase (CDK) inhibitors. Ribociclib works by blocking proteins (CDK4 and CDK6) that promote cancer cell growth, helping to slow or stop the progression of the disease.

How to Take Ribociclib

  • Dosing: The typical starting dose is 600 mg taken orally once daily for 21 consecutive days, followed by 7 days off in a 28-day cycle. Your healthcare provider may adjust your dose based on your response and side effects.
  • Take Ribociclib at the same time each day, with or without food.
  • Do not crush, chew, or split the tablets. Swallow them whole with water.

Possible Side Effects

Ribociclib can cause side effects. Common ones include:

  • Nausea and vomiting
  • Diarrhea
  • Fatigue
  • Decreased appetite
  • Low blood cell counts (e.g., neutropenia, anemia)
  • Hair thinning or loss
  • Elevated liver enzymes (detected in blood tests)

Less common but serious side effects:

  • Heart rhythm problems (QT prolongation)
  • Severe liver problems (yellowing of the skin or eyes, dark urine)
  • Severe infections

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Pregnancy Precautions

  • Do not take Ribociclib if you are pregnant or planning to become pregnant. This medication can harm an unborn baby.
  • Use effective birth control during treatment and for at least 3 weeks after your last dose.
  • If you think you are pregnant while taking Ribociclib, contact your doctor immediately.

Storage

  • Store Ribociclib at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep the medication in its original container, away from moisture and light.
  • Keep out of reach of children.

What to Do If You Miss a Dose

  • If you miss a dose, take it as soon as you remember unless it is within 12 hours of your next scheduled dose.
  • Do not take two doses at the same time. Skip the missed dose if it is too close to your next scheduled dose.

Before Taking Ribociclib, Tell Your Doctor If:

  • You have a history of liver, kidney, or heart problems (e.g., irregular heartbeat).
  • You have low levels of potassium, magnesium, or calcium in your blood.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, vitamins, or herbal supplements.

When to Contact Your Physician

  • Immediately:
    • If you experience symptoms of a severe infection (e.g., fever, chills, persistent cough).
    • If you have symptoms of heart rhythm problems (e.g., fainting, dizziness, irregular heartbeat).
    • Signs of severe liver problems (e.g., yellowing of the skin or eyes, dark urine).
  • As soon as possible:
    • If you experience persistent nausea, vomiting, or diarrhea that does not improve with supportive care.
    • If you notice unusual or severe side effects.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.