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Tamoxifen Patient Handout

What is Tamoxifen?

Tamoxifen is a medication used to treat breast cancer and reduce the risk of developing breast cancer in high-risk individuals. It belongs to a class of drugs called selective estrogen receptor modulators (SERMs). Tamoxifen works by blocking estrogen receptors in breast tissue, which helps to slow or stop the growth of hormone receptor-positive breast cancer.

How to Take Tamoxifen

  • Dosing: The typical dose is 20 mg taken orally once daily. Your healthcare provider may adjust your dose based on your individual needs.
  • Take Tamoxifen at the same time each day, with or without food.
  • Swallow the tablet whole with water. Do not crush or chew the tablet.

Possible Side Effects

Tamoxifen can cause side effects. Common ones include:

  • Hot flashes
  • Vaginal discharge or dryness
  • Nausea
  • Fatigue
  • Changes in menstrual periods

Less common but serious side effects:

  • Blood clots (e.g., deep vein thrombosis or pulmonary embolism)
  • Stroke
  • Uterine cancer
  • Vision changes (e.g., cataracts or blurred vision)

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Pregnancy Precautions

  • Do not take Tamoxifen if you are pregnant or planning to become pregnant. This medication can harm an unborn baby.
  • Use effective non-hormonal birth control during treatment and for at least 2 months after your last dose.
  • If you think you are pregnant while taking Tamoxifen, contact your doctor immediately.

Storage

  • Store Tamoxifen at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep the medication in its original container, away from moisture and light.
  • Keep out of reach of children.

What to Do If You Miss a Dose

  • If you miss a dose, take it as soon as you remember.
  • If it is close to the time for your next dose, skip the missed dose. Do not take two doses at the same time.

Before Taking Tamoxifen, Tell Your Doctor If:

  • You have a history of blood clots, stroke, or other cardiovascular conditions.
  • You have a history of uterine or endometrial cancer.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, vitamins, or herbal supplements.

When to Contact Your Physician

  • Immediately:
    • If you experience symptoms of a blood clot (e.g., swelling, redness, or pain in the legs; chest pain; shortness of breath).
    • If you notice unusual vaginal bleeding or pelvic pain.
    • If you experience severe vision changes.
  • As soon as possible:
    • If you experience persistent nausea, fatigue, or hot flashes that affect your daily life.
    • If you notice unusual or severe side effects.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.