Trastuzumab Patient Handout

What is Trastuzumab?

Trastuzumab is a targeted therapy medication used to treat certain types of cancer, including HER2-positive breast cancer and gastric cancer. It works by targeting the HER2 protein, which is overexpressed in some cancer cells, helping to stop or slow their growth.

How is Trastuzumab Administered?

• Trastuzumab is given as an intravenous (IV) infusion in a hospital or clinic setting. In some cases, it may also be administered as a subcutaneous injection.
• The initial infusion may take up to 90 minutes, while subsequent doses may take 30 minutes.
• The dosing schedule is determined by your healthcare provider and may involve weekly or every-three-week treatments.

Possible Side Effects

Trastuzumab can cause side effects. Common ones include:

• Fatigue
• Nausea
• Diarrhea
• Infusion-related reactions, such as fever, chills, or rash
• Headache

Less common but serious side effects:

• Heart problems, including reduced heart function or heart failure
• Severe lung problems, such as inflammation or difficulty breathing
• Severe allergic reactions

If you experience severe or unusual symptoms, contact your healthcare provider immediately.

Precautions Before Starting Trastuzumab

• Inform your doctor if you have a history of:
  • Heart disease or heart failure
  • Lung problems
  • Any allergies, particularly to medications or proteins
• Discuss all medications, vitamins, or supplements you are taking.
• Use effective contraception during treatment and for at least 7 months after the final dose, as Trastuzumab can harm an unborn baby.

Managing Side Effects

• Infusion-related reactions: Your doctor may give you medications to prevent or reduce these reactions.
• Heart problems: Regular heart monitoring, such as echocardiograms or MUGA scans, may be conducted during treatment. Report any chest pain, shortness of breath, or swelling in your legs.
• Diarrhea: Stay hydrated and consult your doctor for anti-diarrheal medications if needed.
• Fatigue: Rest as needed and maintain a healthy diet.

When to Contact Your Physician

• Immediately:
  • If you experience difficulty breathing, chest pain, or swelling in your legs.
  • If you notice signs of a severe allergic reaction, such as rash, swelling, or difficulty swallowing.
  • If you develop a high fever or severe chills during or after infusion.
• As soon as possible:
  • If you experience persistent nausea, vomiting, or diarrhea.
  • If you notice unusual fatigue or dizziness.
  • If you experience any new or worsening heart-related symptoms.

Storage and Handling

• Trastuzumab is administered by healthcare professionals and is not stored at home.

Disclaimer: This handout is intended for educational purposes only and does not replace professional medical advice. Always follow the guidance of your healthcare provider regarding your medications and health conditions.